James Danforth Quayle (; born February 4, 1947) is an American politician who served as the 44th vice president of the United States from 1989 to 1993 under President George H. W. Bush. A member of the Republican Party, Quayle previously represented Indiana in the House of Representatives from 1977 to 1981 and in the Senate from 1981 to 1989.

A native of Indianapolis, Quayle spent most of his childhood in Paradise Valley, a suburb of Phoenix, Arizona. He married Marilyn Tucker in 1972 and obtained his J.D. degree from the Indiana University Robert H. McKinney School of Law in 1974. He and Marilyn practiced law in Huntington, Indiana, before his election to the United States House of Representatives in 1976. In 1980, he was elected to the U.S. Senate.

In 1988, vice president and Republican presidential nominee George H. W. Bush chose Quayle as his running mate. His vice presidential debate against Lloyd Bentsen was notable for the "Senator, you're no Jack Kennedy" quip. The Bush–Quayle ticket defeated the Democratic ticket of Michael Dukakis and Bentsen, and Quayle became vice president in January 1989. During his tenure, Quayle made official visits to 47 countries and was appointed chairman of the National Space Council. As vice president, he developed a reputation for making gaffes. He secured re-nomination for vice president in 1992, but Democrat Bill Clinton and his running mate Al Gore defeated the Bush–Quayle ticket.

In 1994, Quayle published his memoir, Standing Firm. He declined to run for president in 1996 because of phlebitis. He sought the Republican presidential nomination in 2000, but withdrew his campaign early on and supported the eventual nominee, George W. Bush. He joined Cerberus Capital Management, a private equity firm, in 1999. Since leaving office, Quayle has remained active in the Republican Party, including making several presidential endorsements in 2000, 2012, and 2016.